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87,88,89 As the thymus shrinks, TCR diversity also decreases, impairing the ability of the immune system to respond effectively to novel pathogens 92

We also examined the role of glycosylation by introducing asparagine-to-alanine substitutions at six different potential N -glycosylation sites in surface-targeted LacAnc100, none of which appeared to notably reduce its activity (Supplementary Fig

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