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This in-depth guide compares efficacy, side effects, dosing, cost, and who should consider switching formats

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Risks and Side Effects Cortisone Injections: While cortisone is generally safe for occasional use, repeated injections can have side effects, including: Tissue degeneration (especially in tendons and cartilage) Joint infection (rare but serious) Elevated blood sugar (in diabetic patients) Skin discoloration or thinning Repeated cortisone use has been linked with weakened tendons , potentially leading to ruptures