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In summary, although IBD is a multifactorial disease in which activation of inflammatory cells is thought to play a key role for its development, the synergism between ROS generation and subsequent GSH depletion induced by TNBS appears to be a key event, at least in this model of acute colitis induced by TNBS+ethanol

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This often happens because significant weight lossespecially when achieved quickly through GLP-1 medicationscan lead to the loss of lean muscle mass alongside fat