Normal distributions were applied to all inputs, with the mean obtained from the previous optimisation procedure, and coefficient of variation of 180%
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Acromegalic concerns
Similarly, expression of these transporters was unable to restore the decrease in glutathione levels in our assays (Extended Data Fig
The sorbitol/polyol pathway is similarly increased in the high glucose state, where sorbitol is, in turn, converted to fructose by sorbitol dehydrogenase (SDH), resulting in the production of 3-deoxyglucosone (3DG), a highly reactive -oxo-aldehyde, and promoting the production of AGEs
