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And retatrutide, a triple agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, achieved up to 24% weight loss in early trials

Published June 9, 2021

10.15252/msb.20167422 Mol Syst Biol

The SURPASS-2 trial (N=1,879), published in the New England Journal of Medicine in 2021, used exactly this 4-week step schedule and still reported GI adverse events as the most common reason for discontinuation [3]

The choice between them may matter less than whether any form of B12 should be combined with tirzepatide at all

There are liquid supplements just for people with kidney disease, but you must check with your healthcare provider before taking them, especially if you are on a fluid restriction