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It possesses in vitro balanced GIPR (EC50 = 3 pM) and GLP-1R (EC50 = 5 pM) agonism with relative activity seven times that of GIP to GIPR and five times that of GLP-1 to GLP-1R, respectively (44)

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A randomized, phase 3, open-label trial comparing the effect of the addition of tirzepatide once weekly versus insulin lispro (U100) three times daily in participants with type 2 diabetes inadequately controlled on insulin glargine (U100) with or without metformin (SURPASS-6)

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Devries S., Dalen J.E., Eisenberg D.M., Maizes V., Ornish D., Prasad A., Sierpina V., Weil A.T., Willett W

Highly restrictive diets may lead to deficiencies that make it difficult to heal after surgery

Frias JP, Deenadayalan S, Erichsen L, Knop FK, Lingvay I, Macura S, et al