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T cell responses were predominantly CD 4 rather than CD 8 , despite the HLA-I-targeted design, indicating a preferred activation of CD 4 T cells, potentially attributable to mRNA vaccine expression levels and antigen presentation dynamics

Each peptide interacts with different biological mechanisms, allowing researchers to explore combined pathway activity in controlled models

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These experiments confirmed that cagrilintide is a potent dual agonist, activating both receptor types, which is crucial for its therapeutic effect on reducing food intake and body weight, as demonstrated in preclinical rat models