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Thus, the mutation has survived in the genome in areas where malaria is (or was) prevalent (Africa, Middle East, India, and Southeast Asia)

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For instance, estrogen may interfere with the cross-linking process, leading to a reduction in the mechanical integrity of collagen fibrils

Trends in Biotechnology, 18 (4), 160167

Last reviewed: July 17, 2026 Last updated: July 17, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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