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Similar content being viewed by others Introduction The advent of sodiumglucose co-transporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) has transformed the management of type 2 diabetes (T2D), particularly in individuals with high cardiovascular (CV) and renal diseases [1,2,3,4,5]

Insulin resistance is known to be a key player in the development of HS, hence further research into the effects of GLP-1 agonists is needed as they stimulate glucose dependent insulin secretion

For one, Hcy can be shuttled away to cystathionine, hence, in principle, a block in Hcy remethylation is not immediately a sufficient condition for Hcy elevation

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Such symptoms typically resolve once glucose levels stabilise and do not indicate permanent damage