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In sickle cell anemia oxidative stress can trigger eryptosis and the release of red blood cell microparticles (RBC-MPs), which are small phospholipid-containing vesicles implicated in physiological processes such as hemostasis and potentially linked to macrovascular dysfunction
Following treatment with semaglutide and tirzepatide, the mean post-treatment weight at 6 months was 81.0 (19.0) kg from 90.1 (19.6) kg and 87.6 (28.3) kg from 100.2 (28.5) kg respectively, corresponding to a clinically significant mean weight loss from baseline to 6 months of 10.3 (5.9)% ( p 18 years old) patients who sought management of weight recurrence after SG with semaglutide or tirzepatide from January 2022, at a single private clinic in Kuwait
The Vanderbilt University Medical Center study used sensitivity to GLP receptors as a proxy for the action of the drugs
Future research should include objective measures of pain and inflammation to provide a more accurate assessment of semaglutides effectiveness
Mohamed AM, Isa HM, Ali MS, Dadi A & Kadhim Z 2022
