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Key takeaways: No significant increase in acute pancreatitis risk with tirzepatide No clear doseresponse relationship Consistent findings across randomised trials As the use of GLP-1/GIP agonists continues to expand rapidly, understanding their safety profile is critical not just for clinicians, but for millions of patients worldwide

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Eleftheriadis T, Pissas G, Sounidaki M, et al

Both the glycocalyx and junctional proteins resist solute entry, promoting endothelial cell connectivity [44]