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Compared to the GLP-1RA semaglutide, tirzepatide was a less potent GLP-1RA

could be as high as c.30m by 2030

People using these medicines can lose more weight than with diet and exercise alone a loss of between 5% and 21% of their body weight can be expected depending on which medicine is taken and how long it is used

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Since fibrosis is the most compelling predictor of outcomes, current and future therapies must focus on improving fibrosis by indirectly reducing pro-fibrotic inflammatory signaling or directly abrogating fibrosis

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