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Genetic variants that alter the function of a therapeutic receptor are known to influence drug response through several mechanisms

Animals WT C57BL/6J male mice (The Jackson Laboratory) and heterozygous Bbs5 +/ mice that harbor a -galactosidase (lacZ)tagged, knockout allele of Bbs5 in exon 4 and 5 ( Bbs5 tm1b(EUCOMM)Wtsi ) maintained on a C57BL/6J background (MRC Harwell Institute) were used to produce Bbs5 / mice

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Second, dramatic liver fat clearance

Endogenous peroxidase and alkaline phosphatase (AP) activity was blocked with 3% hydrogen peroxide for 10 minutes