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Its research profile makes it especially relevant for studies focused on fat-cell pathway models, metabolic turnover, energy-balance signaling, methylation-adjacent biology, and body-composition pathway research

For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity

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When overactive, it lowers NAD+ levels and promotes fat accumulation , particularly in visceral (deep belly) fat

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