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It first protects forming sperm as an antioxidant, then becomes structural scaffolding in the mitochondrial capsule of the sperm midpiece, so a selenium shortfall can weaken both protection and the tail's structural integrity

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Nerve growth factor (NGF), released by osteoblasts, endothelial cells, and infiltrating immune cells, plays a key role in promoting this ectopic innervation, establishing a direct link between structural bone changes and pain signaling (Grssel and Muschter, 2017)