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In the future, there is a need for the key markers, such as o-tyrosine, to be determined by the targeted measurement method, which can be further refined for use in clinical laboratory tests for actual patient diagnostics

Its main limitation is the lack of human clinical data specifically for bone healing

Bennett BJ, Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ: Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

This deficiency is more common among people who have had gastric surgeries or pernicious anemia