doi:10.1186/s12916-016-0657-8
Refrigerator storage (2-8 degrees Celsius) Most peptides reconstituted in bacteriostatic water maintain acceptable potency for 3-4 weeks when refrigerated consistently
They measured subjective sleep quality more than objective sleep quality They subjectively estimated tiredness Sleep structure was not fully characterized by polysomnography in all studies Data analysis suggested some observed changes were due to issues with the placebo group What is promising about these findings is that statistically significant effects were found in such small sample sizes
Salmon AB, Richardson A, Perez VI: Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging
Proposed Mechanism BPC-157 appears to work through multiple pathways: Maintaining vesicular integrity (affecting VMATs and dopamine transporters) Possibly occupying its own vesicular storage sites Competing for dopamine receptor binding Functionally substituting when dopaminergic neurons are lost This last property, essentially filling in for missing dopamine function, would explain why the peptide counteracts both receptor agonists (apomorphine) and antagonists (haloperidol, fluphenazine, clozapine, sulpiride) with equal effectiveness
SFN treatment effectively suppresses the accumulation and immunosuppressive functions of myeloid-derived suppressor cells (MDSCs)
