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The same research group reported a mild and efficient method for synthesizing macrocyclic peptides via nitrogen arylation from unprotected precursors

Carter BZ, Mak PY, Mu H, Zhou H, Mak DH, Schober W, Leverson JD, Zhang B, Bhatia R, Konopleva M, Cortes J, Andreeff M

The direction and magnitude of these changes depend on the cell type, inhibitor concentration, exposure time, and assay design

[10] [19] GH stimulation is contraindicated in active malignancy

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