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Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjgrens syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial

Documented side effects are usually mild to moderate: Injection-site pain, redness, or bruising Flushing Increased heart rate Nausea or gastrointestinal upset Headache Urinary changes or a fishy body odor at higher choline doses Because these are compounded products, sterile technique, pharmacy sourcing, and formulation verification matter

While these results are certainly encouraging, they should be regarded as preliminary

Gastroenterology 132(5):20192021

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Syringe selection: Use an insulin syringe with a 29 to 31 gauge needle