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in Cell Metabolism , increased NAD availability stimulates PGC-1 through SIRT1 activation, leading to enhanced mitochondrial function and improved metabolic flexibility (Cant et al., Cell Metabolism )

Only after a lot more work could the link reliably be said to exist, he wrote

MIC B12 injections combine methionine, inositol, choline, and vitamin B12 to potentially enhance metabolism and support fat breakdown

You take metformin or a proton pump inhibitor, which can deplete B12 over time

2) PAS website has section with useful leaflets/articles eg "An Update for Medical Professionals: Diagnosis and Treatment" pernicious-anaemia-society