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& Matthees, D.P

The most common side effects of tirzepatide are gastrointestinal: Nausea: Reported by 12-33% of participants depending on dose (most common early in treatment) Diarrhea: 12-21% of participants Constipation: 6-11% of participants Vomiting: 5-13% of participants Decreased appetite: Expected therapeutic effect but can be uncomfortable These side effects are typically most intense during the first few weeks at each new dose level and tend to improve as the body adjusts

H2 receptors are connected to a cell-mediated inflammatory response and the gut, while H3 receptors are connected to the central nervous system and neurotransmitters

10.1093/jn/128.8.1336 62

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From a pathological intuitive perspective, free radical oxidant production is elevated in any inflamed tissues as a result of our reaction to foreign matter and microorganisms