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These responses occur within half an hour and activate multiple cellular signaling mechanisms, supporting the statement that the cellular response to metal ions and the following signaling pathways are integrated in a signal transduction process [124]

10.1146/annurev-animal-022114-110829 146 MizutaniK.IkedaK.KawaiY.YamoriY

Experimental design considerations include the importance of timing senolytic administration relative to senescence induction or disease progression, as the biological context affects both efficacy and interpretation of results

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It is typically given by a qualified healthcare professional (not self-injected), stored in a cool, dry place, and should be used under medical supervision, especially during pregnancy, breastfeeding, or liver/kidney disease

Stroke (1989), 20:1403-1406