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Gene expression on BDNF and SK-3 was quantified using real-time PCR, revealing that VPA reduced the expression BDNF, which plays a crucial role in synaptic plasticity and neuronal survival, and increased GSK-3, which is involved in neurodevelopment and neuroinflammation whereas crocin dose-dependently normalized both markers (Hosseini et al., 2025)

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Future research should focus on integrating advanced retinal models, synergistic treatment regimens, and rigorous clinical trials to harness the therapeutic potential of GLP-1RAs fully

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