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NO is synthesized by three types of NO synthase (NOS): endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (60)

Mounjaro (Tirzepatide) activates both GIP and GLP-1 receptors (dual mechanism), achieving up to 22.5% weight loss in the SURMOUNT-1 trial

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Data hinted that surgical manipulations of the intestines might markedly dampen the contractile responses to both inducements

However, if you've lost significant weight, your overall metabolic rate may be lower than before starting (smaller body = lower baseline metabolism)

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