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Evidence that the prostate-specific antigen (PSA)/Zn2+ axis may play a role in human prostate cancer cell invasion

This phenomenon is exacerbated by the agerelated decline in the efficiency of the antioxidant system, which becomes insufficient to neutralize excess ROS, leading to oxidative stress and subsequent tissue damage [31]

One hypothesis is that C677Ts reduction in MTHFR activity is likely due to the fact that the alanine to valine amino acid change makes the enzyme more heat-sensitive

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This discovery is of great significance, as it indicates that cell therapy applied to humans can eliminate the need for animal-derived biological materials in culture

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