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The primary endpoint was area under the cagrilintide plasma concentration curve from time zero extrapolated to infinity (AUC 0 ) from baseline (day 1) to day 36 (renal impairment study) or day 39 (hepatic impairment study)

On the 45th day, seizure severity was assessed, and ECoG was recorded using an information integrated biological signal acquisition and processing system (BL-420 N

Clin Transl Gastroenterol 2024;15(11):e00772

Thus, we hypothesized that GLP-1R might participate in the regulation of PKA/CREB signals, which are likely to be involved in inflammatory processes