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While the complex PK process of APAP might be a significant hurdle for this, it is particularly difficult to apply these approaches in pediatric populations due to the dynamic physiology, sample availability, difficulties in monitoring phenotypes, etc

Watanabe, S

Dirksen et al., 2022 ): 1

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S-acetyl glutathione has been shown to cross the membrane of the mitochondria, increasing the organelle's activity and minimizing ROS.(5)