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Kalli, M., & Stylianopoulos, T
Upon activation, NLRP3 engages the scaffold protein NIMA related kinase 7 (NEK7) and recruits the adaptor apoptosis-associated speck-like protein containing a CARD (PYD and CARD domain containing (PYCARD, also known as ASC)) to assemble the inflammasome complex
While clinical trials conducted in Croatia in the early 2000s determined BPC 157 to be safe and effective in humans for the treatment of inflammatory bowel disease, there appears to be a lack of trials conducted in the U.S