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One year after stopping semaglutide 2.4 mg, participants regained two-thirds of their prior weight loss

Avoid greasy, fried, or very high-fat meals that can worsen nausea

Whey, soy, or pea-based shakes are often well tolerated, and for patients experiencing nausea, a shake may be easier to get down than a solid meal

Bottom line The FDA strongly recommends using an FDA-approved semaglutide drug like Ozempic when it is available instead of compounded semaglutide

The retatrutide availability situation and cost considerations remain significant barriers to access, with options for purchasing retatrutide and finding retatrutide online still limited compared to tirzepatide

And GLP-1 can inhibite hepatocyte apoptosis which induced by NLRP3 through autophagy in mitochondria, weakening the intrahepatic inflammatory response, thereby inhibiting the transition from simple fatty liver to nonalcoholic steatohepatitis (NASH)