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Insulin and glucagon dynamics GLP-1 receptor agonists enhance insulin secretion in a glucose-dependent manner, meaning they boost insulin only when blood sugar is elevated

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95,96 Excessive endoplasmic reticulum stress leads to an increase in trypsin activity, which in turn stimulates PAR2 and PAR4 receptors, increases intestinal permeability, destroys the function of the intestinal barrier, and promotes the development of inflammatory processes

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J Mol Biol (2006) 355(4):76883.10.1016/j.jmb.2005.11.014 60 LongeneckerKLStewartKDMadarDJJakobCGFryEHWilkSet alCrystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors