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This may better aid the prediction/detection of human-relevant genotoxic aromatic amine metabolite release at an earlier stage in drug development, and help limit late candidate attrition

Preclinical research Pharmacodynamic research: Evaluating the efficacy of creams in animal models, such as promoting wound healing and anti-inflammatory effects

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10.1007/s00167-018-5321-8 Knee Surg

Sleep is an active biologic process that helps regulate many of the brain's most essential functions, including: Memory consolidation strengthening learning and long-term memory Synaptic plasticity maintaining healthy neural connections Glymphatic function clearing metabolic waste from the brain Neurovascular integrity supporting healthy blood flow & brain function Circadian alignment coordinating the brain's physiologic rhythms A recent review in Seminars in Neurology also highlights that subtle sleep disturbances may precede stroke, Parkinson's disease, Alzheimer's disease, and other neurodegenerative disorders years before clinical symptoms appear, creating an important opportunity for earlier recognition and intervention

doi: 10.1016/j.yebeh.2023.109104 [PubMed] 36988597 Perez DL, Hoch DB, Cohen JN