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Insulin resistance exacerbated pathological PD features which contributed to disease progression via increases in -synuclein accumulation in dopaminergic neurons, oxidative stress, and mitochondrial dysfunction

Sci Rep 8:1603 Sailasuta N, Ananworanich J, Lerdlum S, Sithinamsuwan P, Fletcher JL, Tipsuk S, Pothisri M, Jadwattanakul T, Jirajariyavej S, Chalermchai T, Catella S, Busovaca E, Desai A, Paul R, Valcour V, Group SS (2016) Neuronal-glia markers by magnetic resonance spectroscopy in HIV before and after combination Antiretroviral Therapy

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In laboratory studies, it is examined in relation to signaling processes within experimental models of cellular interaction