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The American Journal of Medicine

doi: 10.1136/annrheumdis-2012-202377 64 GuoY-YWangN-ZZhaoSHouL-XXuY-BZhangN

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[139] conducted in vivo and in vitro experiments and found that the DNA methyltransferase inhibitor Zebularine can reduce the production of pro-inflammatory factors and improve brain edema and nerve function by increasing the expression of ZO-1 and vascular endothelial (VE)-cadherin [131, 132]

While we found that PPAR protein levels appeared to rise throughout differentiation, PPAR protein levels appeared unchanged in stage 6 SC-islets compared to human islets (Fig