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Among the distinct tau transgenic mouse models, senescence was a robust and invariant response to tau accumulation that correlated with brain atrophy in mice and human PSP (35)

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[PubMed] [Google Scholar] 125.Maisonpierre P.C., Suri C., Jones P.F., Bartunkova S., Wiegand S.J., Radziejewski C., Compton D., McClain J., Aldrich T.H., Papadopoulos N., et al

Thus, exploring both genetic and metabolite-based parallels may provide a more holistic understanding of conserved signalling mechanisms underlying stress and degeneration