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This research explores a novel therapeutic avenue by targeting the brains renin-angiotensin system (RAS) and its interaction with the hepatocyte growth factor (HGF)/c-Met receptor system [2]

2.2 Hepatic Impairment Study 2.2.1 Study Population Male and female participants of non-childbearing potential aged between 18 and 80 years with a BMI between 18.5 and 39.9 kg/m 2 were eligible for inclusion in the hepatic impairment study

J Am Soc Nephrol 11:14191425 D'Ercole AJ, Stiles AD, Underwood LE (1984) Tissue concentrations of somatomedin C: further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action

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(2017) The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility, Nat