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This precursor peptide consists of a signal peptide, a glucagon-related polypeptide, glucagon, and GLP-1 and GLP-2
10.1042/bj0010028 54 MllerT
As a result, much of the GLP-1 in intestinal veins is already degraded (46)
About the Author Lisa Catanese, ELS, Health Writer About the Reviewer Howard E
You should not use GLP-1 medications if you have: Personal or family history of medullary thyroid cancer Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Previous severe allergic reaction to semaglutide or liraglutide Current pregnancy or planning to become pregnant History of pancreatitis (requires careful evaluation) Severe gastrointestinal disease Additionally, these medications are not typically recommended for patients under 18 years old, though Saxenda has some pediatric approval for adolescents 12 and older with obesity
Explain the basics of how the medications work
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