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After blocking samples were reduced with TCEP (500 M) for 3 min and re-alkylate with IAM (1 mM) for procedure A and with IAM-TPP (1 mM) for procedure B for 20 min at RT, protected from light

Meldonium, a structural analogue of carnitine used to treat arrhythmias, myocardial infarction, heart failure, and atherosclerosis, inhibits the microbial conversion of carnitine to TMA, ultimately lowering TMAO levelsan effect that offers an additional mechanism for treating atherosclerosis [165, 166]

This requires comprehensive comparability studies against the reference listed drug (RLD), encompassing physicochemical, structural, and biological attributes

Unfortunately, this initial phase often converts toxins into highly reactive intermediate metabolites that are actually more dangerous and damaging than the original substance

doi: 10.1016/j.jaad.2014.07.030 65 Arumi-UriaMMcNuttNSFinnertyB

doi: 10.1134/S000629792003013X 141