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A critical player in maintaining the body's proper functioning, there are three key factors that indicate a glutathione deficiency: Chronic illness or frequent infections Magnesium deficiency Brain-related deficiencies (e.g., seizures, mental delays, loss of coordination) The first factor relates to glutathione's role in the body

These alterations are thought to impact gut barrier integrity and immune function, both of which are implicated in CFS/ME pathophysiology

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Biochem Biophys Res Commun 157:8794 Hindley S, Juurlink BH, Gysbers JW, Middlemiss PJ, Herman MA, Rathbone MP (1997) Nitric oxide donors enhance neurotrophin-induced neurite outgrowth through a cGMP-dependent mechanism