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Clinical Trial Protocols Clinical studies of Retatrutide have so far followed a once-weekly subcutaneous injection model, mirroring the approach used with other GLP-1 receptor agonists like semaglutide and tirzepatide

Nevertheless, preliminary findings suggest that it can maintain weight loss for up to 5 years, given adherence to dietary and lifestyle changes

TRIUMPH-1 reported mean body weight reduction of 28.3% at 80 weeks on the 12 mg arm

Notably, among patients with an ALT more than 2-times the upper limit of normal, levels improved by 46.8 U/L ( P = .01)

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No significant alterations were detected either in circulating FGF21 or adiponectin levels (Suppl