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The trade-off is a very short half-life of approximately 20-30 minutes after subcutaneous injection, making it unsuitable for systemic use and largely studied in local tissue applications [10]

Overall, HCPs highlight the needs for more research to be carried out on the willingness to tolerate side effects and the necessity of weight loss medication

Therefore, it cannot be excluded that the modest reduction in body weight contributed in part to the improvement in insulin sensitivity in all groups

semaglutide or tirzepatide), are of benefit following metabolic surgery

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In clinical trials, participants using retatrutide experienced significant weight loss, with some studies showing an average reduction of up to 24% of body weight