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Dihexa demonstrates unusually high oral bioavailability for a peptide compound, estimated at 40-60% in animal models compared to the typical 5% or less for most peptides

Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)

Lin JL, Thomas PS

Ecotoxicol Environ Saf 6, 32835

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