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Methods of missing data handling are listed in Table 11

Nausea Vomiting Diarrhea Constipation Decreased appetite Injection-site reactions Gallbladder events (cholelithiasis, cholecystitis) reported in some Phase 2 participants Increased heart rate Possible pancreatitis (per GLP-1 class data not specifically reported in retatrutide trials) Frequently asked questions Is retatrutide FDA-approved

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-MSH is a broadly anti-inflammatory neuropeptide that acts on melanocortin receptors to suppress inflammatory mediators, but its melanocortin activity also drives pigmentation and other effects that complicate therapeutic use