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Even though limited, it is worth mentioning that one trial suggested an increased pregnancy rate with pre-gestational exenatide compared with metformin

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PMID 28266027

38,39 However, because of the sympathomimetic effects of phentermine, particularly the potential for increases in heart rate and blood pressure, its use is contraindicated in cardiac disease, including coronary artery disease, uncontrolled hypertension and arrhythmias, as well as cerebrovascular disease

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