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Roncone, R., Barbieri, M., Monzani, E

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In the human condition Fanconi Anaemia, metabolic ROS were shown to induce DNA damage in hematopoietic stem cells (HSCs) when they start cycling to exit quiescence, which impairs blood production in FancA / mice 51

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453,454 These systems ensure that therapeutic concentrations of autophagy modulators reach affected brain regions while minimizing peripheral toxicity