Gastrointestinal adverse events are among the most common reasons for discontinuing treatment with GLP-1 receptor agonists and tirzepatide, but comparative data across these agents in real-world settings have been limited
Pfizer also highlighted Eliquis as a key contributor to its 2024 financial results, accounting for 12% of the companys revenue and serving as its top-selling product last year, having brought in $7.37 billion
These compounds belong to a class called growth hormone-releasing peptides (GHRPs), which directly activate receptors in the brain that trigger the pituitary gland to release natural growth hormone (GH)
In one large study, patients taking topiramate alone lost an average of 11 to 15 pounds over roughly 4 to 7 months or more
How GLP-1 Activation Triggers Loose Stools GLP-1 receptor agonism simultaneously does two critical things to your gut: It slows gastric emptying, meaning food sits in your stomach longer before moving into the small intestine
The most common side effects include nausea, diarrhoea, vomiting, and constipation