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Efskind PS, Bernklev T, Vatn MH

In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by -glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76

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Deficiency can cause disorders such as Keshan disease, a cardiomyopathy seen in selenium-deficient Chinese regions [82]

Yao XK, Sun S, Yu, et al