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CAUTION: Do not exceed recommended dose

LEADER [29] and SUSTAIN-6 [30] reported a prespecified renal composite of new onset or persistent macroalbuminuria, persistent doubling of serum creatinine and eGFR 45 mL/min/1.73 m 2 , need for renal replacement therapy (RRT), and renal death

PubMed, Zhang, Yixiang, et al

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Interestingly, neither tryptophan nor kynurenine nor kynureninic acid concentrations correlated with CRP or GAL3 concentrationssuggesting a complex interplay between inflammatory markers and kynurenine pathway metabolites that warrants further investigation

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