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Additionally, rectal administration can result in higher bioavailability and faster onset of action compared to some other routes, as the medication bypasses the first-pass metabolism in the liver

Noteworthy, when used in the same dose-range, BPC 157 counteracts all of the concomitant gastrointestinal lesions, induced by haloperidol, vesicles depletor reserpine, or neurotoxin affecting substantia nigra 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropropyridine (MPTP) (10, 11, 16)