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At the same time, the pleiotropic, neurotrophic and neuroprotective properties of GLP-1RAs are also obvious and, taking into account the ability to enhance the energy metabolism of neurons and optimize synaptic plasticity these beneficial effects position GLP-1RAs as potential agents modifying brain diseases [109, 110]
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A similar trial (STEP-HFpEF DM) has been conducted in individuals with T2D and HFpEF, demonstrating similar beneficial results (94)
Journal reference: Abbasi et al
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