For a deeper dive into what each trial tests and why, see our retatrutide Phase 3 results breakdown written around TRIUMPH-4, but covering the full program design
Retatrutide is a triple hormone agonist administered by once-weekly injection
Lancet Diabetes & Endocrinology , 7 (11), 834844
Weight Loss and Maintenance Related to the Mechanism of Action of Glucagon-Like Peptide 1 Receptor Agonists Source In both trials, after 72 weeks of treatment, patients who received Zepbound at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of patients who received Zepbound achieved at least 5% weight reduction compared to placebo
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AARP reports 40% of respondents feel the medication is too expensive and 27% say they could not afford it